The carbothermic reaction is analogous to the Kroll process for the conversion of titanium dioxide to titanium tetrachloride. In the laboratory BF3 reacted with AlCl3 gives BCl3 via halogen exchange. BCl3 is a trigonal planar molecule like the other boron trihalides, and has a bond length of 175pm.
A degree of π-bonding has been proposed to explain the short B− Cl distance although there is some debate as to its extent. It does not dimerize, although NMR studies of mixtures of boron trihalides shows the presence of mixed halides. The absence of dimerisation contrasts with the tendencies of AlCl3 and GaCl3, which form dimers or polymers with 4 or 6 coordinate metal centres.
B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9gene.
BCL9, together with its paralogue gene BCL9L (BCL9 like or BCL9.2), have been extensively studied for their role as transcriptional beta-catenin cofactors, fundamental for the transcription of Wnt target genes.
BCL9 and BCL9L have been shown to take part in other tissue-specific molecular mechanisms, showing that their role in the Wnt signaling cascade is only one aspect of their mode of action.
BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.
BCL9 and BCL9L are potential clinical targets for human cancers; for instance, the gene expression changes that they promote is associated with a poor outcome in colorectal cancer.
B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3gene.
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
Back in March of 2020, it was commonplace to witness schools finishing as co-champions in a wide variety of sports ... There’s always a first time for everything ... MelvinWiltshire was named the BCLBoysRunner of the Meet for LatinAcademy as well, as he took first in the 200 (23.64), and second in the 100 (11.42) ... “I know my team put in the work ... ....
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BCL-2 is a validated target for plasma cell diseases and ... BCL-2 and BCL-xL are proteins that play a critical role in the regulation of cell death. The overexpression of BCL-2 and/or BCL-xL are frequently detected in numerous cancer types, which prevent apoptosis of cancer cells.
NEW YORK, March 22, 2022 /PRNewswire/ -- BCL-2(B- cell lymphoma 2) inhibitors Market Facts at a Glance- ... The BCL-2(B- cell lymphoma 2) inhibitors Market is expected to increase by USD 1.43 billion from 2021 to 2026, and the market's growth momentum will accelerate at a CAGR of 12.60% as per the latest market report by Technavio.